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I had to chop a plant that was about 3-4 weeks into flower. I made iso hash from it, and it got me a decent buzz but certainly didn't even begin to compare to the iso I get from the trim of my usual harvests.
I'd say as soon as there are trichomes theres THC being made...in whatever small amounts.
But to answer the OPs question directly...No. Don't waste your time and the plants energy it will use to regenerate it.
-------------------- Of course it's happening inside your head.
Why should that mean it isn't real?