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The important part is making sure your nosal membranes are moist, it doesn't matter too much whether you do it before or after. For a good idea of how to pre-hydrate the membranes, search YouTube for "neti pot", but rather than buying their fancy-looking pot, just use a water bottle.
If your nose feels dry after doing a line, then you didn't do enough
But if you're worried about your nose drying out, it doesn't hurt anything to sniff a couple drops of water after a few minutes.