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 Harry_Ba11sach
cannoisseur
Registered: 04/20/08
Posts: 11,753
Loc: Nepal 
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 A molecular link between the active component of marijuana and Alzheimer's disease pathology. 
#493089 - 10/29/10 08:20 AM (14 years, 1 month ago) |
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www.ncbi.nlm.nih.gov/pubmed/17140265
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, Janda KD.
Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Abstract
Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients and reduce the health care costs attributable to Alzheimer's disease. Here, we demonstrate that the active component of marijuana, Delta9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid beta-peptide (Abeta) aggregation, the key pathological marker of Alzheimer's disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.
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 DieselB
High Watt Closet
Registered: 02/10/10
Posts: 1,156
Last seen: 9 years, 9 months
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Re: A molecular link between the active component of marijuana and Alzheimer's disease pathology. [Re: Harry_Ba11sach]
#493092 - 10/29/10 08:24 AM (14 years, 1 month ago) |
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Thats pretty awesome, cannabinoids win again. Alzheimers is some scary shit too. Another thing somebody told me: in 50 years 1 in 3 will be diabetic. I don't even wanna know if it's true.
Edited by Dr. Siekadellyk (10/29/10 09:04 AM)
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Dr. Siekadellyk
Question Everything!
Registered: 04/20/09
Posts: 9,365
Loc: Ketamine
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Re: A molecular link between the active component of marijuana and Alzheimer's disease pathology. [Re: DieselB]
#493093 - 10/29/10 08:27 AM (14 years, 1 month ago) |
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Quote:
Thats pretty awesome, cannabinoids win again.
 
This right here should be a good enough reason alone to medically legalize it throughout the country.
but no they are not that smarts.
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The Kratom Report...
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DieselB
High Watt Closet
Registered: 02/10/10
Posts: 1,156
Last seen: 9 years, 9 months
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Re: A molecular link between the active component of marijuana and Alzheimer's disease pathology. [Re: Dr. Siekadellyk]
#493105 - 10/29/10 09:01 AM (14 years, 1 month ago) |
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You could've quoted after my non-typin ass edited.
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If you ain't smokin' dro, you're smokin' reggie. 
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Dr. Siekadellyk
Question Everything!
Registered: 04/20/09
Posts: 9,365
Loc: Ketamine
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Re: A molecular link between the active component of marijuana and Alzheimer's disease pathology. [Re: DieselB]
#493106 - 10/29/10 09:04 AM (14 years, 1 month ago) |
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haha I didnt even notice until you mentioned it, but you also still spelled it wrong after the edit.
I'll fix it for you.
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The Kratom Report...
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DieselB
High Watt Closet
Registered: 02/10/10
Posts: 1,156
Last seen: 9 years, 9 months
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Re: A molecular link between the active component of marijuana and Alzheimer's disease pathology. [Re: Dr. Siekadellyk]
#493107 - 10/29/10 09:06 AM (14 years, 1 month ago) |
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I know, and I edited twice!  Wake and bake kicked my ass today.
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If you ain't smokin' dro, you're smokin' reggie.
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