Quote:

---

Psilyguy said:
i dont believe its possible, but people have told me its happened to them. i would believe if i saw some evidence supporting it, but even LSD has been proven that its at least very very hard for it to happen even though everyone thinks it does.

---

Quote:

---

From here:

Substances that are applied to the skin can be systemically absorbed to an unknown extent. However, there have not yet been any quantitative studies of the dermal absorption of THC that would allow quantification. Nevertheless, this question is vital for the use of THC-containing products that are externally applied (cosmetics, dermatics for the treatment of neurodermitis). The physico-chemical characteristics of THC, however, allow a rough estimation of the amount of THC assimilated (Kalbitz et al. 1996, 1997).

Generally, the human skin is well protected against penetration by external substances. Many topically applied substances attain a systemic bioavailability of only a few percent (Hadgraft 1996). The main barrier to penetration is the cornea (stratum corneum), or more accurately, the cornified layer of the stratum corneum. In principle, substances can penetrate the space between the cells of the stratum corneum (intercellular), the cells themselves (intracellular), or the sebaceous and perspiratory glands and hair follicles. Only the first pathways of penetration generally play a relevant role (Hadgraft 1996, Kalbitz et al. 1996, Berti et al. 1995). For example, the route through the hair follicles and glands is of importance for polar molecules only. As a lipophilic molecule, THC does not belong to that group.

The permeation coefficient or, respectively, the permeability constant (Kp) constitute a quantitative expression for the ability of a substance to permeate the skin. The flux or absorption rate of a chemical results from a multiplication of the concentration (C) of a chemical on the skin surface with the permeability constant: flux = KpC (Mattie et al. 1994). The basic principles of absorption through the skin correspond to those of diffusion through semi-permeable membranes (Berti et al. 1995). Factors that influence the penetration through the skin are the thickness and condition of the skin, as well as the size of the penetrating substance and the carrier.

Molecules that enter and diffuse through the skin have to penetrate a number of lipid bilayers in the intercellular space, thereby repeatedly alternating from lipophilic to hydrophilic areas. Those molecules that are sufficiently lipophilic, such as glucocorticoids, easily cross those lipophilic phases. Thus, most publications still maintain as a rule that "highly lipophilic compounds with low molecular weights demonstrate the greatest flow rate through the stratum corneum" (Berti et al. 1995).

Occasionally, a direct relation between the coefficient of permeation and the octanol/water distribution coefficient is postulated (Guy 1995). The latter is a measure of a chemical's lipophilic and hydrophilic properties, respectively. A higher coefficient indicates stronger lipophilic characteristics. However, such a correlation could not be verified in experimental studies. Mattie et al. (1994) examined 13 substances with octanol/water coefficients ranging from zero to 1,400. The constant of permeability correlated only weakly with the octanol/water distribution coefficient (r2 = 0.04).

Instead, there is evidence that only a small fraction of strongly lipophilic substances, such as THC, overcomes the hydrophilic phases of the intercellular space. Gabriele Bast (1997) carried out a large number of experiments that involved different substances of differing lipophilic characteristics in different carriers, and stated: "When substances are applied in a lipophilic carrier the permeation coefficient Kp is notably decreased when the distribution coefficient (n-octanol/perfusion buffer (pH 7.4)) Poct exceeds 2000."

Conclusion: It may validly be assumed that, with an octanol/water distribution coefficient of 6,000 (Agurell et al. 1986), i.e. a strong lipophilic tendency, only a small amount of THC permeates the skin-and is systemically absorbed only on a small scale-when administered in an oily base [my emphasis], such as in cosmetics containing hemp oil. Based on experimental evidence obtained for other chemicals with known physico-chemical properties, the transdermal systemic bioavailability of THC thus is likely considerably less than the oral systemic bioavailability. Corresponding experimental studies should be conducted that quantify the exact rate of skin permeation.

---

Quote:

---

From here:

Absorption of ethyl alcohol into the blood can occur through the skin and via the lungs, though the major route of taking ethyl alcohol into the body is by drinking alcoholic beverages.

Absorption through the skin has been confirmed by a report (Dalt et al, 1991) of a case of a 1 – month old infant who became intoxicated as a result of absorption of ethyl alcohol from dressings applied to the stump of the umbilical cord and the skin adjacent to it.

Additional confirmation of skin absorption comes from a microdialysis study in which a long probe with was inserted under the skin for a distance of 3 cm. Ethyl alcohol was then placed in a small area on the skin above the probe while the subcutaneous area was being perfused. Analysis of the perfusate indicated the presence in an amount that was related to the extent of skin exposure (Anderson et al, 1991).

---

Quote:

---

NobodyImportant said:

there was probably a small amount of alcohol left in it that helped it absorb into your skin faster and that alcohol would have been highly saturated in THCa

---

Quote:

---

NobodyImportant said:

Quote:

---

NobodyImportant said:

there was probably a small amount of alcohol left in it that helped it absorb into your skin faster and that alcohol would have been highly saturated in THCa

---

---

Quote:

---

deladude said:
the absince of evidence isn't the evidence of absince

---

i posted that like a week ago, and spelled it right

but it to be doin thangs and seein swim doin thangs too